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Founding Member
Location: ECU, Perth, Auatralia
Work: Melanoma Developmental Genetics
Biographical: A/Prof Ziman’s research is aimed at understanding developmental genes, and their involvement in cell proliferation, specification and migration. She has studied their expression and regulatory functions in embryogenesis and in adults from several different phyla and utilises mutant mouse models to aid understanding. An area of particular interest is delineation of the importance of developmental genes in specification of melanoblasts and their aberrant re-expression in malignant melanoma cells where they contribute to tumour progression. A collaborative study with leading local and international scientists and clinicians used these developmental genes and other melanoma markers to successfully identify the presence of tumour cells and more importantly, the presence of melanoma stem cells in peripheral blood of patients with Cutaneous Malignant Melanoma. The success of this joint project has led to application for a provisional patent (No:2009900572) and forms the basis of the comprehensive study proposed here. A/Prof Ziman serves on the scientific advisory board of a US biotech company and is an invited member of the ARC/NHMRC Research Network in Genes & Environment in Development (NGED). In 2007 she established the ECU Melanoma Research Foundation to raise awareness of melanoma in the community and funds for melanoma research. A/Prof Ziman has published over 65 papers, and has been an invited speaker at several international cancer/melanoma conferences. She edits scientific text books and is a reviewer for several international funding agencies and scientific journals including Nature Reviews Cancer. She is the past West Australian state representative for the ANZ Society of Cell and Developmental Biology and was a local organising committee member for several conferences. A/Prof Ziman is the leader of her research group on melanoma and developmental genetics. Her research team currently consists of 2 postdoctoral researchers, 4 PhDs, 2 MSc students and one research assistant. Since 2001 she has supervised several students to completion of postgraduate degrees (5 PhDs, 5 MScs and 8 BSc Hons). All PhD graduates have obtained excellent postdoctoral positions in prestigious laboratories worldwide: Cambridge University, UK, Kings College London, UK, Columbia University, New York, USA and University of Pennsylvania, USA. Invited oral presentations: 2008: 8th Anticancer Conference, Greece; World Cancer Congress Shanghai, China; ANS, Hobart; 2007: First World Meeting of Interdisciplinary Melanoma Centres, Barcelona, Spain; 2nd Molecular Mechanisms of Cancer Conference, Queenstown, New Zealand; 2006: Memorial Sloan Kettering Institute, NY, USA; Cambridge University, UK; Inaugural Neurobiology Symposium -Australian Neuroscience Society, Sydney. Conference presentations: 22 International Conferences and 15 National Conferences since 1996 Reviewer International Grants: Cancer Research Grants, UK; Cancer Society of New Zealand; Muscular Dystrophy Campaign Grants, UK; Marsden Fund, New Zealand Reviewer National Grants: NHMRC, ARC, ASMR, Uniserve Science, Innovation awards, WA; Reviewer Journals: Nature Reviews Cancer, Kidney International, Journal of Experimental Biology, International Journal Cancer, Genesis, J. Cell Biol. BMC Development Biology, Critical Reviews Biochemistry & Molecular Biology, Recent Patents DNA & Gene Sequences Reviewer Books: Knox Biology, McGraw Hill: Pharmacology, Pearson Education.
Work: Melanoma Developmental Genetics
Biographical: A/Prof Ziman’s research is aimed at understanding developmental genes, and their involvement in cell proliferation, specification and migration. She has studied their expression and regulatory functions in embryogenesis and in adults from several different phyla and utilises mutant mouse models to aid understanding. An area of particular interest is delineation of the importance of developmental genes in specification of melanoblasts and their aberrant re-expression in malignant melanoma cells where they contribute to tumour progression. A collaborative study with leading local and international scientists and clinicians used these developmental genes and other melanoma markers to successfully identify the presence of tumour cells and more importantly, the presence of melanoma stem cells in peripheral blood of patients with Cutaneous Malignant Melanoma. The success of this joint project has led to application for a provisional patent (No:2009900572) and forms the basis of the comprehensive study proposed here. A/Prof Ziman serves on the scientific advisory board of a US biotech company and is an invited member of the ARC/NHMRC Research Network in Genes & Environment in Development (NGED). In 2007 she established the ECU Melanoma Research Foundation to raise awareness of melanoma in the community and funds for melanoma research. A/Prof Ziman has published over 65 papers, and has been an invited speaker at several international cancer/melanoma conferences. She edits scientific text books and is a reviewer for several international funding agencies and scientific journals including Nature Reviews Cancer. She is the past West Australian state representative for the ANZ Society of Cell and Developmental Biology and was a local organising committee member for several conferences. A/Prof Ziman is the leader of her research group on melanoma and developmental genetics. Her research team currently consists of 2 postdoctoral researchers, 4 PhDs, 2 MSc students and one research assistant. Since 2001 she has supervised several students to completion of postgraduate degrees (5 PhDs, 5 MScs and 8 BSc Hons). All PhD graduates have obtained excellent postdoctoral positions in prestigious laboratories worldwide: Cambridge University, UK, Kings College London, UK, Columbia University, New York, USA and University of Pennsylvania, USA. Invited oral presentations: 2008: 8th Anticancer Conference, Greece; World Cancer Congress Shanghai, China; ANS, Hobart; 2007: First World Meeting of Interdisciplinary Melanoma Centres, Barcelona, Spain; 2nd Molecular Mechanisms of Cancer Conference, Queenstown, New Zealand; 2006: Memorial Sloan Kettering Institute, NY, USA; Cambridge University, UK; Inaugural Neurobiology Symposium -Australian Neuroscience Society, Sydney. Conference presentations: 22 International Conferences and 15 National Conferences since 1996 Reviewer International Grants: Cancer Research Grants, UK; Cancer Society of New Zealand; Muscular Dystrophy Campaign Grants, UK; Marsden Fund, New Zealand Reviewer National Grants: NHMRC, ARC, ASMR, Uniserve Science, Innovation awards, WA; Reviewer Journals: Nature Reviews Cancer, Kidney International, Journal of Experimental Biology, International Journal Cancer, Genesis, J. Cell Biol. BMC Development Biology, Critical Reviews Biochemistry & Molecular Biology, Recent Patents DNA & Gene Sequences Reviewer Books: Knox Biology, McGraw Hill: Pharmacology, Pearson Education.