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@ashutosh
• 4 years ago
• comments: 2
RESEARCH EXPERTISES
Expertise in drug development as well as in basic chemistry. This in details involves, all the organic syntheses, purification by recrystallization techniques, all the chromatography methods, NMR, IR, Mass spectroscopy, etc and its pharmacological evaluation against specific targets.
In pharmaceutical chemistry experienced in Molecular hybridization (MH) technique, used to combine two medicinally important scaffolds such as chromene (different benzopyrans /coumarins /flavones) and dihydropyrimidinone).
Utilized heterogeneous catalyst (SiW (H4W12SiO40), PMo (H3PMo12O40), SiMo (H4SiO4Mo12O36), PW (H3PW12O40)) in organic reactions.
In carbohydrate chemistry synthesis of natural molecule mimicking flavones-C-glycosides and coumarin-C-glycoside modulating traditional carbon-Ferrier rearrangement reaction altering it to one pot Mukaiyama type carbon Ferrier rearrangement reaction.
In natural product chemistry I have isolated different natural molecules such as Flavonoids, xanthones, triterpenes and seccoiridoids from the extracts of 5 different plants including Swertia angustifolia, Pinus gerardina, etc. Different techniques were used for the isolation such as Morphological/Anatomical Analysis, TLC/HPTLC analysis, HPLC Analysis, GC Analysis, Spectroscopic Methods: NMR/MS/NIR/FT-IR. Molecular Biological Methods. Natural product isolation (various Xanthones, Oleanolic acid, beta sitosterol, etc.) and semi-synthetic work on Swertia angustifolia.
Applying green chemistry I have developed a novel method for the synthesis of various chromene dihydropyrimidinone (CDHPM) molecules using recyclable Fe/Al pillared clay catalyst and studied their pharmacokinetic parameters like aqueous solubility, lipophilicity, P-glycoprotein (P-gp) dependent ATPase activity, permeability, plasma protein binding, red blood cell (RBC) partitioning, metabolic stability in liver microsomes and in-vitro-in-vivo computations. Also studied ligand interaction for those compounds with LYS 218 &GLN 220 of NF-kB (PDB: 1NF I) as target protein to study the interaction of DHPMs with the target protein.
Expertise in drug development as well as in basic chemistry. This in details involves, all the organic syntheses, purification by recrystallization techniques, all the chromatography methods, NMR, IR, Mass spectroscopy, etc and its pharmacological evaluation against specific targets.
In pharmaceutical chemistry experienced in Molecular hybridization (MH) technique, used to combine two medicinally important scaffolds such as chromene (different benzopyrans /coumarins /flavones) and dihydropyrimidinone).
Utilized heterogeneous catalyst (SiW (H4W12SiO40), PMo (H3PMo12O40), SiMo (H4SiO4Mo12O36), PW (H3PW12O40)) in organic reactions.
In carbohydrate chemistry synthesis of natural molecule mimicking flavones-C-glycosides and coumarin-C-glycoside modulating traditional carbon-Ferrier rearrangement reaction altering it to one pot Mukaiyama type carbon Ferrier rearrangement reaction.
In natural product chemistry I have isolated different natural molecules such as Flavonoids, xanthones, triterpenes and seccoiridoids from the extracts of 5 different plants including Swertia angustifolia, Pinus gerardina, etc. Different techniques were used for the isolation such as Morphological/Anatomical Analysis, TLC/HPTLC analysis, HPLC Analysis, GC Analysis, Spectroscopic Methods: NMR/MS/NIR/FT-IR. Molecular Biological Methods. Natural product isolation (various Xanthones, Oleanolic acid, beta sitosterol, etc.) and semi-synthetic work on Swertia angustifolia.
Applying green chemistry I have developed a novel method for the synthesis of various chromene dihydropyrimidinone (CDHPM) molecules using recyclable Fe/Al pillared clay catalyst and studied their pharmacokinetic parameters like aqueous solubility, lipophilicity, P-glycoprotein (P-gp) dependent ATPase activity, permeability, plasma protein binding, red blood cell (RBC) partitioning, metabolic stability in liver microsomes and in-vitro-in-vivo computations. Also studied ligand interaction for those compounds with LYS 218 &GLN 220 of NF-kB (PDB: 1NF I) as target protein to study the interaction of DHPMs with the target protein.
Dear Prof. Ashutosh,
Thanks very much for joining our network and your detailed biography!
If I may, would like to contact you regarding some of my own interests in plant chemistry (I am a botanist, not a chemist, but work with Araceae, which have very interesting biochemical defences).
Best regards, Peter (Admin., Kyoto)
PROFILE A proficient in Medicinal chemistry/ Organic chemistry/ Basic chemistry/pharmaceutical sciences with an experience of 9 years in research and academic sector. Over the years developed expertise in basic as well as applied research (medicinal/ pharmaceutical chemistry; natural product based medicinal chemistry and carbohydrate chemistry) as an assistant professor and researcher in the Natural Product Chemistry division of CSIR-Indian Institute of Integrative Medicine, (IIIM) Jammu. Have experienced in methodologies in translation research like non-infringing routes for the synthesis of APIs and synthesis of drug active metabolites using green chemistry. In natural product chemistry I have expertise in natural product chemistry; which includes isolation of secondary metabolites from microbial and plant sources, DOS, semi-synthetic modifications and medicinal chemistry against specific targets in cancer, diabetics, inflammation, etc. Having a pharmaceutical science educational background, a clear understanding of the subjects beyond research area has been achieved. Expertise in drug development process commencing from synthesizing, optimizing up to its detailed pharmacology. Sincere efforts for synthesizing new drug discovery targeting these vital aspects of cancer and have good working experience with methodologies in organic chemistry has been achieved. Has published expensively in peer-reviewed journals, also published book chapters up to December 2019. In an academic role, has successfully mentored doctoral research scholar (1 Ph.D.) and M. Pharm students (12 Dissertations) as well as B. Pharm students (30 dissertations). I’m imparting my experience in research, mentoring and leadership skills amongst the students of Shoolini University, Solan, HP and teaching them medicinal chemistry.