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Location: India
Work: Anti-cancer research, Exploring Chemistry of Imidazothiadiazole and 2-oxindole derivatives, Ruthenium complexes as anticancer,
Biographical: Corresponding address :KLE University’s College of Pharmacy 2nd Block, Post Box No: 1062 Rajajinagar, Bangalore-560 010, INDIA, +91-80-23325611 (Dept)+91-80-23425373 (Fax)+91-9448017123 (cell)subhasskarki@gmail.com Achievements 1. Indian Patent Filed (Appl. No. 2713/CHE/2012) on 04/07/2012. “Compounds as Inhibitors of DNA Double Strand Break Repair, Methods & Applications Thereof” 2. World patent filed (PCT IB 2013051798) on 07/03/2013. “Compounds as Inhibitors of DNA Double Strand Break Repair, Methods & Applications Thereof” 2. First rank to Karnataka University, Dharwad during M Pharm. 3. Awarded Boyscast Fellowship for 2006-07 from DST, New Delhi [Ref. NO.SR/BY/L-25/06]. Membership of Professional Bodies 1. Life Member- Association of Pharmaceutical Teachers of India (APTI) 2. Registered Member, Karnataka State Pharmacy Council, Bangalore. 3. Member, Board of studies in Pharmacy (PG Studies & Research), KLE University, Belgaum. 4. Member, Board of Inter-disciplinary Studies and Research, KLE University, Belgaum. Grants completed:3 • 2007-2008, Boyscast fellowship at College of Pharmacy & Nutrition, University of Sasketchewan, Saskatoon, Canada. Collaborative Research 1. National Institute of Health, Bethesda, USA for anticancer activity. 2. Prof. Dr. Erick De Clercq, Rega Institute for Medical Research, Minderbroedersstraat, 10, B-3000, Leuven, Belgium, for Cytotoxicity and Antiviral activity. 3. Dept. of Engineering Physics, MS Ramaih College of Engineering, Bangalore, for X-ray crystal study. 4. Biochemistry Dept., Indian Institute of Science, Bangalore, for anticancer activity. 5. Division of Microbiology and Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD, for screening against M. tuberculosis strain H37Rv. 6. Anticonvulsant Screening Program, Office of Translational Research, NIH/NINDS Rockville, MD for anticonvulsant activity. Reviewer European Journal of Medicinal Chemistry Bioorganic & Medicinal Chemistry Oriental Pharmacy & Experimental Medicine (OPEM) Journal of Heterocyclic Chemistry Medicinal Chemistry Research Archiv der Pharmazie Journal of the Science of Food and Agriculture M Pharm Projects Guided-18 Ph D Thesis Guided-05/undergoing-05 Presentation of Papers at Conferences / Seminars: International-08 Visited countris 1. University of Leicester, Leicester, UK. 2. University of Saskatchewan, Saskatoon, Canada. AS A RESOURCE PERSON • Delivered a talk on “Role of FTIR in Drug Design” at a national Conference organized by IPS College of Pharmacy, Gwalior, Madhya Pradesh on 31-03-2010. • Delivered lecture on “Hallmarks of Cancer-The Next Generation” at AICTE-sponsered National Seminar organized by Academy of Pharmaceutical Sciences, Periyaram Medical College PO, Kannur, Kerala on 28-11-2013. • Delivered a lecture on “Drug Design & Development” at AICTE-sponsored Staff Development Programme organized by Acharya & BM Reddy College of Pharmacy, Bangalore on 29-07-2010. • Appointed as guest faculty by BITS, Pilani for off campus program at Strides Arcolab, Limited (Course: MS Pharmaceutical Operations & Management) WORKSHOPS/CONFERENCES/SYMPOSIUMS ATTENDED. 1. Workshop on "Scanning electron microscope for beginners" held at University science instrumentation center Jadavpur university, Kolkata-700 032 (INDIA) July 23 and 26 (2002). 2. Workshop on "Bio-Informatics & its application" under CEP at IIT-Kharagpur (INDIA) September 28-29 (2001). 3. Quality improvement programme on “Trends in pharmaceutical analysis and approaches towards drug design” at College of pharmacy (Belgaum) and AICTE (New Delhi) 18-31 August 2003. 4. Workshop on “Molecular Modeling and Pharmainformatics” held at National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Chandiharh, (INDIA) Nov 1-5, 2004. 5. Attended workshop on “Research Methodologies, Biostatistics and Research Ethics” held at Rajiv Gandhi University of Health Sciences, Bangalore, (Karnataka) Aug 2004. 6. Workshop on “Science of Scientific Writing” held at GM Rejoyz Digital Auditorium & Banquet, Bangalore (INDIA) April 23rd, 2005. 7. IUPAC sponsored “2nd International symposium on Green/sustainable chemistry” held at Delhi university, Delhi, India.10-13, January 2006. 8. “2nd International conference on Drug Design and Process Research” held at KLES College of Pharmacy, Belgaum, Karnataka, India, 10-12, February 2006. 9. “2nd International conference on Heterocyclic Chemistry” held at Dept. of Chemistry, University of Rajasthan, Jaipur, India, 16-19, December 2006. 10. Workshop on “Novel Concept of Pharmaceutical Research & Process Validation” on 25th & 26th July 2011, organized by KLE University’s College of Pharmacy, Bangalore. 11. National conference on “Mile Stones of Chemistry in the last 100 Years” at S. Nijalingappa College, Bangalore on 10th Sep, 2011. 12. “63rd Indian Pharmaceutical Congress (IPC)” at Bangaluru from 16-18th December 2011 as Local Organising Committee. 13. “National Seminar on Quality Assurance in Health Science Institutions” sponsored by NAAC & organized by KLE University, Belgaum on 2nd & 3rd Jan, 2012. 14. UGC Sponsored National Seminar on “The Role of Chemistry in Medicine” held on 22nd Feb, 2012 at MES Degree College, Malleswaram, Bangalore. 15. “Workshop on Writing Research Proposals for External Funding” held at Rajiv Gandhi University of Health Sciences, Bangalore on 28th April, 2012 List of Significant Publications PUBLISHED PAPERS/ACCEPTED [(51) National: 17 & International: 34] 1. “Synthesis and biological evaluation of 5-Formyl-6-arylimidazo-(2,1-b)-1,3,4-thiadiazole-2N-(dimethylaminomethino)-sulfonamides as Antitumor Agents” AK. Gadad, SS. Karki, VG. Rajurkar and BA. Bhongade. Arzneim.- Forsch./Drug Res. 49(II), 10, 858-863 (1999). 2003 2. “Synthesis, antitumor and antibacterial activity of some Ru(bpy)22+/4-substituted thiosemicarbazide complexes”. UK. Mazumder, M. Gupta, A Bera, S. Bhattacharya, SS. Karki, L. Manikandan and S. Patra. Ind. J. of Chem. 42A. 313-317 (2003). 3. “Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models” M. Gupta, UK. Mazumder, T. Sivakumar, MLM. Vamsi, SS. Karki, R. Sambathkumar, L. Manikandan. Biol. Pharm. Bull. 26(9), (2003). 4. “Antioxidant status and anti-inflammatory activity of methanol extract of Acalypha fruticosa in experimental animal models”. M. Gupta, UK. Mazumder, T. Sivakumar, MLM. Vamsi, SS. Karki, R. Sambathkumar and L. Manikanda. Nigerian Journal of Natural Products & Medicine. Vol. 7, 25-29, (2003). 2004 5. “Synthesis, Anticancer and antibacterial activity of some novel mononuclear Ru(II) complexes”. M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh and T. Sivakumar. Chem. Pharm. Bull. 52(2), 178-185 (2004). 6. “Synthesis and biological activity of some mononuclear Ru(II) compleses”. M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh and T. Sivakumar. J. of Enz. Inh. and Med. Chem 15(2), 185-192 (2004). 2005 7. “Synthesis and Pharmacological Activities of some Mononuclear Ru(II) Complexes” M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh and T. Sivakumar. Bioorg. and Med. Chem., 13, (20) 5766-5773, (2005). 8. “Antitumor and antioxidant activities of Bryonia laciniosa against Ehrlich’s Ascites Carcinoma bearing Swiss albino mice” T Sivakumar, R Sambath Kumar, P Perumal, MLM Vamsi, P Sivakumar, R Kanagasabai1, MV Baskaran, SS. Karki, UK Mazumder and M Gupta. Oriental Pharmacy and Experimental Medicine 5(4), 322-330, (2005). 2006 9. “Synthesis, Anticancer activity of certain mononuclear Ru(II) complexes”. M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh. J. of Enz. Inh. and Med. Chem Vol 21, No. 5, 501-507, (2006). 10. “Crystal Structure of 6-(4-Chlorophenyl-)-imidazo-(2,1-b)-1,3,4-thiadiazole-2-sulfonamide” GN. Anilkumar, MK. Kokila, Puttaraja, SS. Karki, MV. Kulkarni. Acta Crystallographica Section E, 62, 02014-02016, (2006). 2007 11. “Synthesis, anticancer and cytotoxic activities of some mononuclear ruthenium (II) compounds” SS. Karki, T. Shreekanth, YD, Satyanarayana, J. Balzarini and EDe. Clerck. Bioorganic Medicinal Chemistry, 2007, 15(21); 6632-6641. 12. “Antidiabetic activity of herb of cynodon dactylon linn. Pers. In alloxan induced diabetic rats and in euglycemic rats” Neeli GS. Girase GS. Kute SH, Karki SS. Shaikh MI. Indian Drugs, 44(8), 602-605, 2007. 13. “Hypoglycemic effect of leaves of Lawsonia Alba in alloxan induced diabetic rats and glycemic rats” Neeli GS. Kute SH, Girase GS, Karki SS. Shaikh MI. Indian Drugs, 44(7), 561-563, 2007. 14. “Influence of beta-cyclodextrin complexation on glipizide release from hydroxypropyl methylcellulose matrix tablets” Shivakumar HN, Desai BG, Pandya S, Karki SS, PDA J Pharm Sci Technol. 61(6):472-91, 2007. 15. “Prodrug Concept: Prodrugs of Ibuprofen” Kulkarni A. A, Karki S. S, Kapse S, Chitlange S. S, Cheterji N. C, Current Pharma Research Journal, 1(4), 95-98, 2007. 2009 16. “1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazone as leads for developing cytotoxins and anticonvulsants” SS. Karki, VS. Bahaduria, V Rana, S Kumar, GS Prasanna, U Das, J. Balzarini, EDe. Clercq and JR. Dimmock. J. of Enz. Inh. and Med. Chem. 24(2), 537-544, 2009. 17. “Development and Validation of gas Chromatographic method for estimation of organic volatile impurities in some ayurvedic preparation” Rahul Hazare, A.V.Chandewar, Subhas S. Karki. Asian Journal of Chemistry. 21(9), 6993-98, 2009. 18. Validation of gas chromatographic system for estmation of organic volatole impurities in hydro alcoholic formulation”Rahul Hazare, A.V.Chandewar, Subhas S. Karki. International Journal of Chemical Sciences. 7(2), 689-708, 2009. 19. “Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-]quinoxalines” Subhas S. Karki, Rahul Hazare, Sujeet Kumar, Vivek S. Bhadauria, Jan Balzarini, Erik De Clercq. Acta Pharmaceutica. 59, 431-440 (2009). 20. “Synthesis, Charecterisation and antibacterial activity of some novel mononuclear Ru(II) Complexes” Sreekanth Thota, Subhas S Karki Babu Rao Bhukya. International Journal of Pharmacy and P’cal Sciences. 1(2), 62-70, 2009. 2010 21. “Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes” Thota S, Karki SS, Jayaveera KN, Balzarini J, Clercq ED. J Enzyme Inhib Med Chem. 25(4), 513-519, 2010. 22. “Formulation and Evaluation of Ranitidine Hydrochloride Mouth Dissolving Tablet by Effervescent Formulation Technique” Vinodh Kumar S Mannur, Subhas S Karki, Ayaz A Dhada. Research J. Pharm. & Tech. 3(2): 2-4, 2010. 23. “Formulation and Characterization of Ranitidine Hydrochloride Fast disintegrating Tablets” V.S. Mannur, Subhas S. Karki, Ketan B. Ramani. International Journal of Chem Tech Research, 2, 1163-1169, 2010. 24. “Synthesis and cytotoxic activity of some mononuclear Ru(II) Complexes” Sreekanth Thota, Subhas S. Karki, Jayaveera KN, Jan Balzarini, Erik De Clercq. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(3), 2010, 704-713. 25. “Synthesis and Biological Evaluation of Some Novel Substituted N- Benzylideneaniline Derivatives” Subhas S Karki, Santosh R. Butle, Rizwan M. Shaikh, P. K. Zubaidha, Ganesh S. Pedgaonkar, Girish S. Shendarkar, Chitra G. Rajput. Research Journal of Pharmaceutical, Biological and Chemical Sciences 1(4), 707-717, 2010. 26. “Studies on anticonvulsant activity of stem barks of calotropis gigantin linn. In experimental animals”Subhas S Karki, Suresh Babu AR, International J. of Pharmaceutical Sciences Review and Research, 5(1), 114-116, 2010. 27. “Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes” Sreekanth Thota; Subhas S. Karki; K. N. Jayaveera; Jan Balzarini; Erik De Clercq, Journal of Coordination Chemistry, 4332-4346, 63(24), 2010. (IF:1.547) 2011 28. “Synthesis and Biological evaluation of some Stilbene-based analogues” Subhas S. Karki, Santosh R. Bhutle, Ganesh S. Pedgaonkar, P. K. Zubaidha, Rizwan M. Shaikh, Chitra G. Rajput, Girish S. Shendarkar. Medicinal Chemistry Research 20, 1158-1163, 2011. (IF: 1.271) 29. “Synthesis and Cytostatic evaluation of some 2-(5-substituted-2-oxoindolin-3- ylidene)-N-substituted hydrazine carbothioamide” Subhas S Karki, Amol Kulkarni, Nishith Therai, Erik De Clercq, Jan Balzarini. Medicinal Chemistry Research 20, 1229-1234, 2011. (IF: 1.271) 30. “Synthesis and biological evaluation of some stilbene derivatives” Subhas S Karki, Santosh R. Butle, Subhas Sahu, Ratnakar Reddy, YD Satyanarayana, Jan Balzarini, Erik De, Clerq. Medicinal Chemistry Research 20, 1349–1356 2011. (IF: 1.271) 31. ‘’Synthesis and antimicrobial activity of some 3-substituted-2-oxindole derivatives” Subhas S Karki, Rahul Hazare, Sujeet Kumar, Amit Saxena, Arpit Katiyar. Turkish Journal of Pharmaceutical Sciences, 8(2), 169-178, 2011. 32. “Synthesis, characterization and cytotoxic activity of some Ru(II) complexes” Subhas S. Karki, Sreekanth Thota, Arpit Katiyar, Korlakunta. N. Jayaveera, Erik De Clercq, Jan Balzarini. Turkish Journal of Pharmaceutical Sciences, 8(3), 207-218, 2011. 33. “Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4’-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents” Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella and Sathees C. Raghavan, European Journal of Medicinal Chemistry, 46, 2109-2116, 2011. 34. “Anti-inflammatory efficacy of various extracts of Calotropis procera leaves against different inflammation models.” Subhas S. Karki, Suresh Babu AR Journal of Herbal Medicine & Toxicology. 5(2), 41-46, 2011. 35. “Antiinflammatory activity of various extracts of roots of Calotropis Procera against different inflammation models.” Suresh Babu, A. R., Subhas S. Karki, International Journal of Pharmacy and Pharmaceutical Sciences 3(3), 191-194, 2011. 36. “Anticonvulsant activity of various extracts of leaves of Calotropis Gigantea Linn against seizres induced models. Suresh Babu, A. R., Subhas S. Karki, International Journal of Pharmacy and Pharmaceutical Sciences 3(3), 200-203, 2011. 37. “Synthesis and Antimicrobial Evaluation of Some Fused Iminopyrimidobenzothiaz- ole Derivatives” G. R. Shendarkar, L. B. Labhsetwar, S. R. Butle, S. S. Karki, R. H.Sharma, S.V.Kuberkar, Int. J. Res. Pharm. & Biomed. Sci., 2(3), 1350-1356, 2011. 2012 38. “Synthesis, Spectroscopic characterization, Antineoplastic, Invitro-cytotoxic and Antibacterial activity of some novel mononuclear Ruthenium(II) Complexes.” Sreekanth Thota, Subhas S. Karki, Journal of Coordination Chemistry 65 (5), 823–839, 2012. (IF:1.547) 39. “Wound Healing Activity of Caloptropis Gigantea Leaves in Albino Wistar Rats” SureshBabu AR, Subhas S. Karki, Int. J. of Pharmacy 2(1), 195-199, 2012. 40. “Synthesis, spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(II) complexes” Sreekanth Thota, Mohammad Imran, Manasa Udugula, Rajeshwar Yerra, Subhas S. Karki, Jan Balzarini, Erik De Clercq, Chinese Chemical Letters 23(4), 466–469, 2012. (IF: 1.271) 41. “In vitro cytotoxicity and induction of apoptosis by ruthenium (II) complexes in HL-60 and K-562” S. Bhattacharya, Subhas S. Karki, R. Suresh, L. Manikandan, G.P. Senthilkumar, M. Gupta, Upal K. Mazumder, R. Balaji , K. Murali. Medicinal Chemistry Research 21, 1120-1126, 2012. (IF: 1.271) 42. “Microwave-Assisted Synthesis of Some Imidazo[2,1-b][1,3,4]thiadiazole Derivatives” Subhas S. Karki, Sharad Dhepe, Sujeet Kumar, Vinaya Kumar R, Suresh Babu AR, Medicinal Chemistry Research 21, 1550-1556, 2012. (IF: 1.271) 43. “Identification of a Novel Inhibitor of Nonhomologous DNA End Joining: Implications in DNA Double-strand Break Repair, Apoptosis and Cancer’’ Mrinal Srivastava, Mridula Nambiar, Sheetal Sharma, Subhas S. Karki, G. Goldsmith, Mahesh Hegde, Sujeet Kumar, Monica Pandey, Ram K. Singh, Pritha Ray, Kuppusamy Panjamurthy, Renuka Natarajan, Madhura Kelkar, Michael R. Lieber, Abhijit De, Bibha Choudhary, Sathees C. Raghavan. Cell 151, 1474-1487, 2012 (IF: 32.403) 44. ‘’Novel Levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice’’ Mahesh Hegde, Subhas S. Karki, Elizabeth Thomas, Sujeet Kumar, Kuppusamy Panjamurthy, Ranganatha S. R, Kanchugarakoppal S. Rangappa, Bibha Choudhary, Sathees C. Raghavan. PLoS ONE. 7 (9), 43632, 2012(IF: 4.07) 45. “Microwave Assisted Synthesis, Characterization of Some New Isatin and Thiophene Derivatives as Cytotoxic and Chemopreventive Agents” Kiran Gangarapu, Sarangapani Manda, Sreekanth Thota, Rajeshwar Yerra, Subhas S. Karki, Jan Balzarini, Erik De Clercq, Harukuni Tokuda. Lett. in Drug Design & Discovery. 9, 934 – 941, 2012 (IF: 0.872) 46. “Synthesis, antimicrobial screening and beta lactamase inhibitory activity of 3-(3- chloro-4-fluorophenylimino) indolin-2-one and 5-chloro indolin-2-one derivatives” Subhas S. Karki, Amol A. Kulkarni, Sreekanth Thota, Sheetal Nikam, Amit S. Kamble, Nagesh D. Dhawale, Turkish Journal of Pharmaceutical Sciences. 9(3), 353-358, 2012. 2013 47. “Synthesis and Biological Evaluation of 2-(5-substituted-1-((diethylamino) methyl)-2-oxoindolin-3-ylidene)-N-substitutedhydrazinecarbothioamides” Subhas S. Karki, Amol A. Kulkarni, Suresh Kumar Veliyath, Sujeet Kumar, Erik De Clercq, Jan Balzarini. Medicinal Chemistry Research 22, 2014-2022, 2013. (IF: 1.612) 48. “Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biological activities” Kiran Gangarapu, Sarangapani Manda, Anvesh Jallapally, Sreekanth Thota, Subhas S. Karki, Jan Balzarini, Erik De Clercq, Harukuni Tokuda. Medicinal Chemistry Research 23, 1046-1056, 2014. (IF: 1.612). 49. “2-(4’-chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and study of mechanism of action” Sujeet Kumar, Mahesh Hegde, Vinaya Kumar R, Shweta Tiwari, Sureshbabu A. Ramareddy, Vidya Gopalakrishnan, Erik De Clercq, Jan Balzarini, and Subhas S. Karki. (In Press) 50. Synthesis and Antiproliferative Activity of Imidazo[2,1-b][1,3,4]thiadiazole Derivatives Sujeet Kumar, Vidya Gopalakrishnan, Mahesh Hegde, Vivek Rana, Sharad S. Dhepe, Sureshbabu A. Ramareddy, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Mrinal Srivastava, Sathees C. Raghavan, Subhas S. Karki. (In Press) REFERENCES: 1. Dr. SM. Hipparagi Principal, KLE University’s College of Pharmacy 2nd Block, Rajajinagar, Bangalore-560010 080-23325611 (college) 080-23425373 (fax) bgdesai2000@yahoo.com 2. Dr. Jonathan R. Dimmock Emeritus Professor College of Pharmacy & Nutrition University of Saskatchewan, Saskatoon, Canada S7H4Z9. jr.dimmock@usask.ca Tel: 306-966-6331. Fax: 306-966-6377
Favourite Publications: Nature, Cell, Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry
Work: Anti-cancer research, Exploring Chemistry of Imidazothiadiazole and 2-oxindole derivatives, Ruthenium complexes as anticancer,
Biographical: Corresponding address :KLE University’s College of Pharmacy 2nd Block, Post Box No: 1062 Rajajinagar, Bangalore-560 010, INDIA, +91-80-23325611 (Dept)+91-80-23425373 (Fax)+91-9448017123 (cell)subhasskarki@gmail.com Achievements 1. Indian Patent Filed (Appl. No. 2713/CHE/2012) on 04/07/2012. “Compounds as Inhibitors of DNA Double Strand Break Repair, Methods & Applications Thereof” 2. World patent filed (PCT IB 2013051798) on 07/03/2013. “Compounds as Inhibitors of DNA Double Strand Break Repair, Methods & Applications Thereof” 2. First rank to Karnataka University, Dharwad during M Pharm. 3. Awarded Boyscast Fellowship for 2006-07 from DST, New Delhi [Ref. NO.SR/BY/L-25/06]. Membership of Professional Bodies 1. Life Member- Association of Pharmaceutical Teachers of India (APTI) 2. Registered Member, Karnataka State Pharmacy Council, Bangalore. 3. Member, Board of studies in Pharmacy (PG Studies & Research), KLE University, Belgaum. 4. Member, Board of Inter-disciplinary Studies and Research, KLE University, Belgaum. Grants completed:3 • 2007-2008, Boyscast fellowship at College of Pharmacy & Nutrition, University of Sasketchewan, Saskatoon, Canada. Collaborative Research 1. National Institute of Health, Bethesda, USA for anticancer activity. 2. Prof. Dr. Erick De Clercq, Rega Institute for Medical Research, Minderbroedersstraat, 10, B-3000, Leuven, Belgium, for Cytotoxicity and Antiviral activity. 3. Dept. of Engineering Physics, MS Ramaih College of Engineering, Bangalore, for X-ray crystal study. 4. Biochemistry Dept., Indian Institute of Science, Bangalore, for anticancer activity. 5. Division of Microbiology and Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD, for screening against M. tuberculosis strain H37Rv. 6. Anticonvulsant Screening Program, Office of Translational Research, NIH/NINDS Rockville, MD for anticonvulsant activity. Reviewer European Journal of Medicinal Chemistry Bioorganic & Medicinal Chemistry Oriental Pharmacy & Experimental Medicine (OPEM) Journal of Heterocyclic Chemistry Medicinal Chemistry Research Archiv der Pharmazie Journal of the Science of Food and Agriculture M Pharm Projects Guided-18 Ph D Thesis Guided-05/undergoing-05 Presentation of Papers at Conferences / Seminars: International-08 Visited countris 1. University of Leicester, Leicester, UK. 2. University of Saskatchewan, Saskatoon, Canada. AS A RESOURCE PERSON • Delivered a talk on “Role of FTIR in Drug Design” at a national Conference organized by IPS College of Pharmacy, Gwalior, Madhya Pradesh on 31-03-2010. • Delivered lecture on “Hallmarks of Cancer-The Next Generation” at AICTE-sponsered National Seminar organized by Academy of Pharmaceutical Sciences, Periyaram Medical College PO, Kannur, Kerala on 28-11-2013. • Delivered a lecture on “Drug Design & Development” at AICTE-sponsored Staff Development Programme organized by Acharya & BM Reddy College of Pharmacy, Bangalore on 29-07-2010. • Appointed as guest faculty by BITS, Pilani for off campus program at Strides Arcolab, Limited (Course: MS Pharmaceutical Operations & Management) WORKSHOPS/CONFERENCES/SYMPOSIUMS ATTENDED. 1. Workshop on "Scanning electron microscope for beginners" held at University science instrumentation center Jadavpur university, Kolkata-700 032 (INDIA) July 23 and 26 (2002). 2. Workshop on "Bio-Informatics & its application" under CEP at IIT-Kharagpur (INDIA) September 28-29 (2001). 3. Quality improvement programme on “Trends in pharmaceutical analysis and approaches towards drug design” at College of pharmacy (Belgaum) and AICTE (New Delhi) 18-31 August 2003. 4. Workshop on “Molecular Modeling and Pharmainformatics” held at National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Chandiharh, (INDIA) Nov 1-5, 2004. 5. Attended workshop on “Research Methodologies, Biostatistics and Research Ethics” held at Rajiv Gandhi University of Health Sciences, Bangalore, (Karnataka) Aug 2004. 6. Workshop on “Science of Scientific Writing” held at GM Rejoyz Digital Auditorium & Banquet, Bangalore (INDIA) April 23rd, 2005. 7. IUPAC sponsored “2nd International symposium on Green/sustainable chemistry” held at Delhi university, Delhi, India.10-13, January 2006. 8. “2nd International conference on Drug Design and Process Research” held at KLES College of Pharmacy, Belgaum, Karnataka, India, 10-12, February 2006. 9. “2nd International conference on Heterocyclic Chemistry” held at Dept. of Chemistry, University of Rajasthan, Jaipur, India, 16-19, December 2006. 10. Workshop on “Novel Concept of Pharmaceutical Research & Process Validation” on 25th & 26th July 2011, organized by KLE University’s College of Pharmacy, Bangalore. 11. National conference on “Mile Stones of Chemistry in the last 100 Years” at S. Nijalingappa College, Bangalore on 10th Sep, 2011. 12. “63rd Indian Pharmaceutical Congress (IPC)” at Bangaluru from 16-18th December 2011 as Local Organising Committee. 13. “National Seminar on Quality Assurance in Health Science Institutions” sponsored by NAAC & organized by KLE University, Belgaum on 2nd & 3rd Jan, 2012. 14. UGC Sponsored National Seminar on “The Role of Chemistry in Medicine” held on 22nd Feb, 2012 at MES Degree College, Malleswaram, Bangalore. 15. “Workshop on Writing Research Proposals for External Funding” held at Rajiv Gandhi University of Health Sciences, Bangalore on 28th April, 2012 List of Significant Publications PUBLISHED PAPERS/ACCEPTED [(51) National: 17 & International: 34] 1. “Synthesis and biological evaluation of 5-Formyl-6-arylimidazo-(2,1-b)-1,3,4-thiadiazole-2N-(dimethylaminomethino)-sulfonamides as Antitumor Agents” AK. Gadad, SS. Karki, VG. Rajurkar and BA. Bhongade. Arzneim.- Forsch./Drug Res. 49(II), 10, 858-863 (1999). 2003 2. “Synthesis, antitumor and antibacterial activity of some Ru(bpy)22+/4-substituted thiosemicarbazide complexes”. UK. Mazumder, M. Gupta, A Bera, S. Bhattacharya, SS. Karki, L. Manikandan and S. Patra. Ind. J. of Chem. 42A. 313-317 (2003). 3. “Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models” M. Gupta, UK. Mazumder, T. Sivakumar, MLM. Vamsi, SS. Karki, R. Sambathkumar, L. Manikandan. Biol. Pharm. Bull. 26(9), (2003). 4. “Antioxidant status and anti-inflammatory activity of methanol extract of Acalypha fruticosa in experimental animal models”. M. Gupta, UK. Mazumder, T. Sivakumar, MLM. Vamsi, SS. Karki, R. Sambathkumar and L. Manikanda. Nigerian Journal of Natural Products & Medicine. Vol. 7, 25-29, (2003). 2004 5. “Synthesis, Anticancer and antibacterial activity of some novel mononuclear Ru(II) complexes”. M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh and T. Sivakumar. Chem. Pharm. Bull. 52(2), 178-185 (2004). 6. “Synthesis and biological activity of some mononuclear Ru(II) compleses”. M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh and T. Sivakumar. J. of Enz. Inh. and Med. Chem 15(2), 185-192 (2004). 2005 7. “Synthesis and Pharmacological Activities of some Mononuclear Ru(II) Complexes” M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh and T. Sivakumar. Bioorg. and Med. Chem., 13, (20) 5766-5773, (2005). 8. “Antitumor and antioxidant activities of Bryonia laciniosa against Ehrlich’s Ascites Carcinoma bearing Swiss albino mice” T Sivakumar, R Sambath Kumar, P Perumal, MLM Vamsi, P Sivakumar, R Kanagasabai1, MV Baskaran, SS. Karki, UK Mazumder and M Gupta. Oriental Pharmacy and Experimental Medicine 5(4), 322-330, (2005). 2006 9. “Synthesis, Anticancer activity of certain mononuclear Ru(II) complexes”. M. Gupta, UK. Mazumder, SS. Karki, S. Bhattacharya, R. Suresh. J. of Enz. Inh. and Med. Chem Vol 21, No. 5, 501-507, (2006). 10. “Crystal Structure of 6-(4-Chlorophenyl-)-imidazo-(2,1-b)-1,3,4-thiadiazole-2-sulfonamide” GN. Anilkumar, MK. Kokila, Puttaraja, SS. Karki, MV. Kulkarni. Acta Crystallographica Section E, 62, 02014-02016, (2006). 2007 11. “Synthesis, anticancer and cytotoxic activities of some mononuclear ruthenium (II) compounds” SS. Karki, T. Shreekanth, YD, Satyanarayana, J. Balzarini and EDe. Clerck. Bioorganic Medicinal Chemistry, 2007, 15(21); 6632-6641. 12. “Antidiabetic activity of herb of cynodon dactylon linn. Pers. In alloxan induced diabetic rats and in euglycemic rats” Neeli GS. Girase GS. Kute SH, Karki SS. Shaikh MI. Indian Drugs, 44(8), 602-605, 2007. 13. “Hypoglycemic effect of leaves of Lawsonia Alba in alloxan induced diabetic rats and glycemic rats” Neeli GS. Kute SH, Girase GS, Karki SS. Shaikh MI. Indian Drugs, 44(7), 561-563, 2007. 14. “Influence of beta-cyclodextrin complexation on glipizide release from hydroxypropyl methylcellulose matrix tablets” Shivakumar HN, Desai BG, Pandya S, Karki SS, PDA J Pharm Sci Technol. 61(6):472-91, 2007. 15. “Prodrug Concept: Prodrugs of Ibuprofen” Kulkarni A. A, Karki S. S, Kapse S, Chitlange S. S, Cheterji N. C, Current Pharma Research Journal, 1(4), 95-98, 2007. 2009 16. “1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazone as leads for developing cytotoxins and anticonvulsants” SS. Karki, VS. Bahaduria, V Rana, S Kumar, GS Prasanna, U Das, J. Balzarini, EDe. Clercq and JR. Dimmock. J. of Enz. Inh. and Med. Chem. 24(2), 537-544, 2009. 17. “Development and Validation of gas Chromatographic method for estimation of organic volatile impurities in some ayurvedic preparation” Rahul Hazare, A.V.Chandewar, Subhas S. Karki. Asian Journal of Chemistry. 21(9), 6993-98, 2009. 18. Validation of gas chromatographic system for estmation of organic volatole impurities in hydro alcoholic formulation”Rahul Hazare, A.V.Chandewar, Subhas S. Karki. International Journal of Chemical Sciences. 7(2), 689-708, 2009. 19. “Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-]quinoxalines” Subhas S. Karki, Rahul Hazare, Sujeet Kumar, Vivek S. Bhadauria, Jan Balzarini, Erik De Clercq. Acta Pharmaceutica. 59, 431-440 (2009). 20. “Synthesis, Charecterisation and antibacterial activity of some novel mononuclear Ru(II) Complexes” Sreekanth Thota, Subhas S Karki Babu Rao Bhukya. International Journal of Pharmacy and P’cal Sciences. 1(2), 62-70, 2009. 2010 21. “Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes” Thota S, Karki SS, Jayaveera KN, Balzarini J, Clercq ED. J Enzyme Inhib Med Chem. 25(4), 513-519, 2010. 22. “Formulation and Evaluation of Ranitidine Hydrochloride Mouth Dissolving Tablet by Effervescent Formulation Technique” Vinodh Kumar S Mannur, Subhas S Karki, Ayaz A Dhada. Research J. Pharm. & Tech. 3(2): 2-4, 2010. 23. “Formulation and Characterization of Ranitidine Hydrochloride Fast disintegrating Tablets” V.S. Mannur, Subhas S. Karki, Ketan B. Ramani. International Journal of Chem Tech Research, 2, 1163-1169, 2010. 24. “Synthesis and cytotoxic activity of some mononuclear Ru(II) Complexes” Sreekanth Thota, Subhas S. Karki, Jayaveera KN, Jan Balzarini, Erik De Clercq. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1(3), 2010, 704-713. 25. “Synthesis and Biological Evaluation of Some Novel Substituted N- Benzylideneaniline Derivatives” Subhas S Karki, Santosh R. Butle, Rizwan M. Shaikh, P. K. Zubaidha, Ganesh S. Pedgaonkar, Girish S. Shendarkar, Chitra G. Rajput. Research Journal of Pharmaceutical, Biological and Chemical Sciences 1(4), 707-717, 2010. 26. “Studies on anticonvulsant activity of stem barks of calotropis gigantin linn. In experimental animals”Subhas S Karki, Suresh Babu AR, International J. of Pharmaceutical Sciences Review and Research, 5(1), 114-116, 2010. 27. “Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes” Sreekanth Thota; Subhas S. Karki; K. N. Jayaveera; Jan Balzarini; Erik De Clercq, Journal of Coordination Chemistry, 4332-4346, 63(24), 2010. (IF:1.547) 2011 28. “Synthesis and Biological evaluation of some Stilbene-based analogues” Subhas S. Karki, Santosh R. Bhutle, Ganesh S. Pedgaonkar, P. K. Zubaidha, Rizwan M. Shaikh, Chitra G. Rajput, Girish S. Shendarkar. Medicinal Chemistry Research 20, 1158-1163, 2011. (IF: 1.271) 29. “Synthesis and Cytostatic evaluation of some 2-(5-substituted-2-oxoindolin-3- ylidene)-N-substituted hydrazine carbothioamide” Subhas S Karki, Amol Kulkarni, Nishith Therai, Erik De Clercq, Jan Balzarini. Medicinal Chemistry Research 20, 1229-1234, 2011. (IF: 1.271) 30. “Synthesis and biological evaluation of some stilbene derivatives” Subhas S Karki, Santosh R. Butle, Subhas Sahu, Ratnakar Reddy, YD Satyanarayana, Jan Balzarini, Erik De, Clerq. Medicinal Chemistry Research 20, 1349–1356 2011. (IF: 1.271) 31. ‘’Synthesis and antimicrobial activity of some 3-substituted-2-oxindole derivatives” Subhas S Karki, Rahul Hazare, Sujeet Kumar, Amit Saxena, Arpit Katiyar. Turkish Journal of Pharmaceutical Sciences, 8(2), 169-178, 2011. 32. “Synthesis, characterization and cytotoxic activity of some Ru(II) complexes” Subhas S. Karki, Sreekanth Thota, Arpit Katiyar, Korlakunta. N. Jayaveera, Erik De Clercq, Jan Balzarini. Turkish Journal of Pharmaceutical Sciences, 8(3), 207-218, 2011. 33. “Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4’-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents” Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella and Sathees C. Raghavan, European Journal of Medicinal Chemistry, 46, 2109-2116, 2011. 34. “Anti-inflammatory efficacy of various extracts of Calotropis procera leaves against different inflammation models.” Subhas S. Karki, Suresh Babu AR Journal of Herbal Medicine & Toxicology. 5(2), 41-46, 2011. 35. “Antiinflammatory activity of various extracts of roots of Calotropis Procera against different inflammation models.” Suresh Babu, A. R., Subhas S. Karki, International Journal of Pharmacy and Pharmaceutical Sciences 3(3), 191-194, 2011. 36. “Anticonvulsant activity of various extracts of leaves of Calotropis Gigantea Linn against seizres induced models. Suresh Babu, A. R., Subhas S. Karki, International Journal of Pharmacy and Pharmaceutical Sciences 3(3), 200-203, 2011. 37. “Synthesis and Antimicrobial Evaluation of Some Fused Iminopyrimidobenzothiaz- ole Derivatives” G. R. Shendarkar, L. B. Labhsetwar, S. R. Butle, S. S. Karki, R. H.Sharma, S.V.Kuberkar, Int. J. Res. Pharm. & Biomed. Sci., 2(3), 1350-1356, 2011. 2012 38. “Synthesis, Spectroscopic characterization, Antineoplastic, Invitro-cytotoxic and Antibacterial activity of some novel mononuclear Ruthenium(II) Complexes.” Sreekanth Thota, Subhas S. Karki, Journal of Coordination Chemistry 65 (5), 823–839, 2012. (IF:1.547) 39. “Wound Healing Activity of Caloptropis Gigantea Leaves in Albino Wistar Rats” SureshBabu AR, Subhas S. Karki, Int. J. of Pharmacy 2(1), 195-199, 2012. 40. “Synthesis, spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(II) complexes” Sreekanth Thota, Mohammad Imran, Manasa Udugula, Rajeshwar Yerra, Subhas S. Karki, Jan Balzarini, Erik De Clercq, Chinese Chemical Letters 23(4), 466–469, 2012. (IF: 1.271) 41. “In vitro cytotoxicity and induction of apoptosis by ruthenium (II) complexes in HL-60 and K-562” S. Bhattacharya, Subhas S. Karki, R. Suresh, L. Manikandan, G.P. Senthilkumar, M. Gupta, Upal K. Mazumder, R. Balaji , K. Murali. Medicinal Chemistry Research 21, 1120-1126, 2012. (IF: 1.271) 42. “Microwave-Assisted Synthesis of Some Imidazo[2,1-b][1,3,4]thiadiazole Derivatives” Subhas S. Karki, Sharad Dhepe, Sujeet Kumar, Vinaya Kumar R, Suresh Babu AR, Medicinal Chemistry Research 21, 1550-1556, 2012. (IF: 1.271) 43. “Identification of a Novel Inhibitor of Nonhomologous DNA End Joining: Implications in DNA Double-strand Break Repair, Apoptosis and Cancer’’ Mrinal Srivastava, Mridula Nambiar, Sheetal Sharma, Subhas S. Karki, G. Goldsmith, Mahesh Hegde, Sujeet Kumar, Monica Pandey, Ram K. Singh, Pritha Ray, Kuppusamy Panjamurthy, Renuka Natarajan, Madhura Kelkar, Michael R. Lieber, Abhijit De, Bibha Choudhary, Sathees C. Raghavan. Cell 151, 1474-1487, 2012 (IF: 32.403) 44. ‘’Novel Levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice’’ Mahesh Hegde, Subhas S. Karki, Elizabeth Thomas, Sujeet Kumar, Kuppusamy Panjamurthy, Ranganatha S. R, Kanchugarakoppal S. Rangappa, Bibha Choudhary, Sathees C. Raghavan. PLoS ONE. 7 (9), 43632, 2012(IF: 4.07) 45. “Microwave Assisted Synthesis, Characterization of Some New Isatin and Thiophene Derivatives as Cytotoxic and Chemopreventive Agents” Kiran Gangarapu, Sarangapani Manda, Sreekanth Thota, Rajeshwar Yerra, Subhas S. Karki, Jan Balzarini, Erik De Clercq, Harukuni Tokuda. Lett. in Drug Design & Discovery. 9, 934 – 941, 2012 (IF: 0.872) 46. “Synthesis, antimicrobial screening and beta lactamase inhibitory activity of 3-(3- chloro-4-fluorophenylimino) indolin-2-one and 5-chloro indolin-2-one derivatives” Subhas S. Karki, Amol A. Kulkarni, Sreekanth Thota, Sheetal Nikam, Amit S. Kamble, Nagesh D. Dhawale, Turkish Journal of Pharmaceutical Sciences. 9(3), 353-358, 2012. 2013 47. “Synthesis and Biological Evaluation of 2-(5-substituted-1-((diethylamino) methyl)-2-oxoindolin-3-ylidene)-N-substitutedhydrazinecarbothioamides” Subhas S. Karki, Amol A. Kulkarni, Suresh Kumar Veliyath, Sujeet Kumar, Erik De Clercq, Jan Balzarini. Medicinal Chemistry Research 22, 2014-2022, 2013. (IF: 1.612) 48. “Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biological activities” Kiran Gangarapu, Sarangapani Manda, Anvesh Jallapally, Sreekanth Thota, Subhas S. Karki, Jan Balzarini, Erik De Clercq, Harukuni Tokuda. Medicinal Chemistry Research 23, 1046-1056, 2014. (IF: 1.612). 49. “2-(4’-chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and study of mechanism of action” Sujeet Kumar, Mahesh Hegde, Vinaya Kumar R, Shweta Tiwari, Sureshbabu A. Ramareddy, Vidya Gopalakrishnan, Erik De Clercq, Jan Balzarini, and Subhas S. Karki. (In Press) 50. Synthesis and Antiproliferative Activity of Imidazo[2,1-b][1,3,4]thiadiazole Derivatives Sujeet Kumar, Vidya Gopalakrishnan, Mahesh Hegde, Vivek Rana, Sharad S. Dhepe, Sureshbabu A. Ramareddy, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Mrinal Srivastava, Sathees C. Raghavan, Subhas S. Karki. (In Press) REFERENCES: 1. Dr. SM. Hipparagi Principal, KLE University’s College of Pharmacy 2nd Block, Rajajinagar, Bangalore-560010 080-23325611 (college) 080-23425373 (fax) bgdesai2000@yahoo.com 2. Dr. Jonathan R. Dimmock Emeritus Professor College of Pharmacy & Nutrition University of Saskatchewan, Saskatoon, Canada S7H4Z9. jr.dimmock@usask.ca Tel: 306-966-6331. Fax: 306-966-6377
Favourite Publications: Nature, Cell, Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry
